The Possible Mechanisms Underlying Epinephrine Worsens Bupivacaine Induced Cardiac Toxicity
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چکیده
experimental animals. But which occurs first and is more important? Put another way, do patients with bupivacaine toxicity die of arrhythmias, contractile failure, or a combination of the two? Epinephrine is a first-line agent for treating cardiac arrest; but why patients who have undergone bupivacaine induced cardiac arrest are often resistant to adrenergic therapy? This article reviews the mechanism underlying bupivacaine induced cardiac collapse, and the effect of epinephrine on the toxicity.
منابع مشابه
Epinephrine reversed high-concentration bupivacaine- induced inhibition of calcium channels and transient outward potassium current channels, but not on sodium channel in ventricular myocytes of rats
BACKGROUND Epinephrine is a first-line drug for cardiopulmonary resuscitation, but its efficacy in the treatment of bupivacaine-induced cardiac toxicity is still in question. We hypothesized that epinephrine can reverse cardiac inhibition of bupivacaine by modulating ion flows through the ventricular myocyte membrane channels of rats. The aim of this study was to observe and report the effects ...
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